▲CAR-T细胞识别CD19阳性壁细胞造成血脑屏障通透性增加的示意图(图片来源:参考资料[1])Posey教授说:“接下来的问题是,我们能否找到一种比CD19更好的靶点来消除B细胞相关的恶性肿瘤,或者,我们能不能构建一种新的CAR-T细胞,根据遇到的细胞类型来做出决定,比如遇到B细胞就杀死它们,遇到CD19阳性的脑细胞则放过它们。”要实现后一种目标,研究人员指出,下一代CAR-T细胞或许可以通过区分目标抗原的特定组合,来提高识别细胞类型的能力。我们期待这项发现带来的洞见能够早日转化为更安全、更有效的临床疗法,造福患者。参考资料[1] Kevin R. Parker et al., (2020) Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Cell. DOI: https://doi.org/10.1016/j.cell.2020.08.022[2] Penn researchers discover potential cause of immunotherapy-related neurotoxicity. Retrieved Sep. 22, 2020, from https://www.pennmedicine.org/news/news-releases/2020/september/penn-researchers-discover-potential-cause-of-immunotherapy-related-neurotoxicity